Placebo Response Reduction

Reduce placebo response in patient reported outcomes: Neutralize patient expectations of treatment benefit

Placebo response leads to failed studies. If your next trial includes a placebo, you need WCG Analgesic Solutions’ Placebo Response Reduction training program.

Patient expectations drive placebo response, and placebo response—along with the accuracy of patient- and clinician-reported outcomes—strongly influences the outcome of a clinical trials. So to diminish placebo response, you must neutralize the subject’s expectation that the treatment will be of benefit.

That’s what we do. WCG Analgesic Solutions’ Placebo Response Reduction program provides a psychoeducational approach to training monitors, staff and subjects. The goal: Encourage neutral expectations from subjects and reduce measurement error, which leads to more successful trials.

We now know that well-trained research staff not only can avoid passing their biases down to the patients but can help patients neutralize their own expectations.

Neutralize patient expectations. Improve accuracy. Schedule a consultation today.

Placebo Response Reduction is Powered by WCG Analgesic Solutions

As precision medicine advances, ensuring data quality has become a tremendous challenge, especially in CNS trials. Missed signals, measurement errors and, of course, placebo response risk undermining them.

The team at WCG Analgesic Solutions has the people, processes and technology to overcome these challenges. Our world-class consulting, monitoring, risk-assessment tools, training and analytics services identify and mitigate the errors that put your clinical trial at risk.

A data-driven strategy to improve the signal-to-noise ratio

Analgesic Solutions advises research sponsors on protocol design and development, regulatory and FDA submissions, and signal-to-noise optimization. Combining deep subject matter expertise with unmatched experience in data-quality risk assessment, measurement-error reduction and data surveillance, we offer an array of data-driven solutions:

Data-Quality Risk Assessment

Our team of experts will review your study’s protocol and identify a systematic approach to assessment and planning to detect errors early and reduce measurement error in a study.

Measurement-Error Reduction

Our evidence-based Accurate Pain Reporting and Placebo Response Reduction training mitigate variance in pain reporting and reduce placebo response in pain clinical trials.

Abuse-Risk Detection

We developed MADDERS® (Misuse, Abuse, and Diversion Drug Event Reporting System) in collaboration with the FDA-ACTTION initiative to meet the need for a standardized approach to quantifying abuse potential in investigational therapeutics.

Data Surveillance

Our Quantitative Data Surveillance System (QDSS) utilizes statistical process control to monitor clinical trials. This approach helps identify and correct issues at the subject, site and trial levels, sponsors to maximize assay and endpoint sensitivity as they meet scientific and regulatory expectations for data quality.

Explore Placebo Response Reduction for your study

Complete the form to request a schedule a consultation. We’ll assess your needs, review our training service and demonstrate how WCG can reduce placebo response for your study.