Industry trends show that a major contributor to trial failure is the increased rate of placebo response, while at the same time, placebo response across multiple therapeutic areas is now historically high and progressively increasing. Multiple reviews in different therapeutic areas including pain, neurology, psychiatry, dermatology, pediatric studies, etc. suggest a very distressing trend in that, year-over-year, the rates of placebo response are increasing dramatically.
The question we must ask ourselves: How can these trends be reversed?
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