More Guidance, Less Variability: Digital EDSS Givers Raters a More Precise, More User-Friendly Tool for MS Assessments

CNS researchers have been using the EDSS (Expanded Disability Status Scale) for years to quantify the severity of disability in patients with multiple sclerosis and other neurological conditions. However, with more than 130 data points, this scale can be cumbersome to complete on paper, leaving it vulnerable to inaccuracies, including interrater and intrarater variability.1 To […]

A Therapy for TRD? Psilocybin Appears to Help Some Patients, WCG-Supported Study Finds

For decades, researchers have looked for ways to treat patients with treatment-resistant depression (TRD). Psilocybin, a psychedelic compound found in certain mushrooms, may be one answer, according to research published in the New England Journal of Medicine.1 A Phase II clinical trial demonstrated the feasibility of synthetic psilocybin monotherapy for up to 12 weeks for […]

Protecting Patients, Protecting Your Study: The Benefits Of A Well-Run Data Monitoring Committee

Everything rests on having the right Data Monitoring Committee (DMC) in place. A well-run DMC protects patient safety and ensures data integrity. A poorly run one puts patients—and the trial itself—at risk. DMCs are independent groups of experts, typically clinicians and statisticians, who monitor patient safety and sometimes treatment efficacy data during a clinical trial. […]

Quiz: Test Your Knowledge on Depressive Disorders

  References Depression and Other Common Mental Disorders: Global Health Estimates. Geneva: World Health Organization; 2017. Licence: CC BY-NC-SA 3.0 IGO. Prevalence of depression among adults aged 20 and over: United States, 2013–2016. Brody DJ, Pratt LA, Hughes J.  NCHS Data Brief, no 303. Hyattsville, MD: National Center for Health Statistics. 2018. The State Of […]

Unsustainable and Burdensome: Today’s Safety Reporting Fails Sites, Sponsors and Patients

The way most sponsors and CROs approach safety reporting overburdens sites. Sponsors bombard sites with safety notifications, many of them unnecessary. Sites are overwhelmed to the point they may miss the critical patient-safety information.    Safety reporting is one of the last areas of hidden cost and inefficiency in clinical trials today, costing sponsors millions […]

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