Using PANSS Score Profiles to Predict Early Termination in a Study on Acute Exacerbation of Schizophrenia

Blinded analyses were aimed to determine how different atypical Positive and Negative Syndrome Scale (PANSS) score profiles (identified using algorithms) were able to predict early termination.

About the Author

Dr. Mark Opler, PhD, MPH | Chief Research Officer

Dr. Mark Opler serves as Chief Research Officer, directing scientific research and development at MedAvante-ProPhase. Dr. Opler was the founder of ProPhase and served as its CEO and Chief Scientific Officer among other positions. He holds the titles of Adjunct Assistant Professor of Psychiatry at New York University and Assistant Professor of Clinical Neuroscience at Columbia University’s College of Physicians and Surgeons. His academic research focuses on the etiology, phenomenology, and treatment of serious and persistent mental disorders. He is also leading the development of the new upcoming edition of the PANSS Manual©.

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Using scoring algorithms to identify serious scoring violations among placebo responders and non-responders in clinical trials using the Pos
Using scoring algorithms to identify serious scoring violations among placebo responders and non-responders in clinical trials using the Pos

The objective was to use a priori scoring algorithm designed to assess violations and non-violations on PAN...